Lipoic acid-boronophenylalanine-derived multifunctional vesicles for cancer chemoradiotherapy

Lipoic acid-boronophenylalanine-derived multifunctional vesicles for cancer chemoradiotherapy

Blog Article

Abstract Cancer remains a major health challenge, with the effectiveness of chemotherapy often limited by its lack of specificity and systemic toxicity.Nanotechnology, particularly in targeted drug delivery, has emerged as a key innovation to address these limitations.This study introduces lipoic acid-boronophenylalanine (LA-BPA) derivatives that incorporate short-chain polyethylene glycol (PEG) as a spacer.These derivatives distinctively self-assemble into vesicles under specific pH conditions, exhibiting a pH-dependent reversible assembly characteristic.

Notably, these vesicles target cancer cells by binding to sialic acid via phenylboronic acid groups, subsequently depleting cellular glutathione and Omega 3-6-9 Fish elevating reactive oxygen 2 Piece Sofa Chaise species, thereby inducing apoptosis via mitochondrial dysfunction and mitophagy.The vesicles demonstrate high efficiency in encapsulating doxorubicin, featuring a glutathione-responsive release mechanism, which present a promising option for tumor therapy.Additionally, the derivatives of the B-10 isotope, containing up to 1.6% boron, are engineered for incorporation into L P B-3-based vesicles.

This design facilitates their application in boron neutron capture therapy (BNCT) alongside chemotherapy for the treatment of pancreatic cancer.Our findings highlight the potential of LA-BPA derivatives in developing more precise, effective, and less detrimental chemoradiotherapy approaches, marking an advancement in nanomedicine for cancer treatment.